Artemisone effective against murine cerebral malaria

45Citations
Citations of this article
44Readers
Mendeley users who have this article in their library.

Abstract

Background. Artemisinins are the newest class of drug approved for malaria treatment. Due to their unique mechanism of action, rapid effect on Plasmodium, and high efficacy in vivo, artemisinins have become essential components of malaria treatment. Administration of artemisinin derivatives in combination with other anti-plasmodials has become the first-line treatment for uncomplicated falciparum malaria. However, their efficiency in cases of cerebral malaria (CM) remains to be determined. Methods. The efficacy of several artemisinin derivatives for treatment of experimental CM was evaluated in ICR or C57BL/6 mice infected by Plasmodium berghei ANKA. Both mouse strains serve as murine models for CM. Results. Artemisone was the most efficient drug tested, and could prevent death even when administered at relatively late stages of cerebral pathogenesis. No parasite resistance to artemisone was detected in recrudescence. Co-administration of artemisone together with chloroquine was more effective than monotherapy with either drug, and led to complete cure. Artemiside was even more effective than artemisone, but this substance has yet to be submitted to preclinical toxicological evaluation. Conclusions. Altogether, the results support the use of artemisone for combined therapy of CM. © 2010 Waknine-Grinberg et al; licensee BioMed Central Ltd.

Cite

CITATION STYLE

APA

Waknine-Grinberg, J. H., Hunt, N., Bentura-Marciano, A., McQuillan, J. A., Chan, H. W., Chan, W. C., … Golenser, J. (2010). Artemisone effective against murine cerebral malaria. Malaria Journal, 9(1). https://doi.org/10.1186/1475-2875-9-227

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free