The poor reparative potential of articular cartilage is largely attributed to its avascular and aneural status combined with low cellularity; chondrocytes only occupy 10% of the tissue volume.
W Archer, C. (2016). Articular Cartilage-Derived Stem Cells: Identification, Characterisation and their Role in Spontaneous Repair. Rheumatology: Current Research, 01(S3). https://doi.org/10.4172/2161-1149.s3-005