Association of Haemostatic and Inflammatory Biomarkers with Nephropathy in Type 1 Diabetes Mellitus

  • Pereira Domingueti C
  • Bastos Fóscolo R
  • Sepúlveda Reis J
  • et al.
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Abstract

This study aimed at investigating the association between haemostatic biomarkers, proinflammatory, and anti-inflammatory cytokines with chronic kidney disease in type 1 diabetic patients. Patients were divided into two groups: with nephropathy (albuminuria ≥ 30 mg/g and/or GFR < 60 mL/min/1.73 m 2), í µí±› = 65; and without nephropathy (albuminuria < 30 mg/g and GFR ≥ 60 mL/min/1.73 m 2), í µí±› = 60. INF-í µí»¾, IL-6, IL-10, and TNF-í µí»¼ plasma levels were determined by flow cytometry. VWF, ADAMTS13 antigen, and D-Dimer plasma levels were determined by enzyme-linked immunosorbent assay and ADAMTS13 activity was assessed by fluorescence resonance energy transfer assay. Elevated levels of INF-í µí»¾, VWF, ADAMTS13 antigen, D-Dimer, and reduced ADAMTS13 activity/antigen ratio were observed in patients with nephropathy as compared to those without nephropathy (í µí±ƒ = 0.001, í µí±ƒ < 0.001, í µí±ƒ < 0.001, í µí±ƒ < 0.001, and í µí±ƒ < 0.001, resp.). Cytokines and haemostatic biomarkers remained associated with nephropathy after adjustments (use of statin, acetylsalicylic acid, angiotensin converting enzyme inhibitor, and angiotensin antagonist). INF-í µí»¾, TNF-í µí»¼, and IL-10 significantly correlated with haemostatic biomarkers. Inflammatory and hypercoagulability status are associated with nephropathy in type 1 diabetes mellitus and an interrelationship between them may play an important role in pathogenesis of diabetic nephropathy.

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Pereira Domingueti, C., Bastos Fóscolo, R., Sepúlveda Reis, J., Magalhães Freire Campos, F., Maria Dusse, L. S., das Graças Carvalho, M., … Paula Fernandes, A. (2016). Association of Haemostatic and Inflammatory Biomarkers with Nephropathy in Type 1 Diabetes Mellitus. Journal of Diabetes Research, 2016. https://doi.org/10.1155/2016/2315260

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