The associations of fetuin-a with subclinical cardiovascular disease in community-dwelling persons: The Rancho Bernardo study

41Citations
Citations of this article
25Readers
Mendeley users who have this article in their library.

Abstract

Objectives: The aim of this study was to determine the association of fetuin-A with subclinical cardiovascular disease (CVD) in community-living individuals. Background: Fetuin-A is a hepatic secretory protein that inhibits arterial calcium deposition in vitro. Lower fetuin-A levels are associated with arterial calcification and death in end-stage renal disease populations. The association of fetuin-A with subclinical CVD in the general population is unknown. Methods: Among 1,375 community-living individuals without prevalent clinical CVD, we measured plasma fetuin-A concentrations. Peripheral arterial disease (PAD) was defined by ankle brachial index <0.90, coronary artery calcification (CAC) was measured by computed tomography, and common and internal intima-media thickness (cIMT) were measured by carotid ultrasound. PAD was measured concurrent with fetuin-A, and CAC and cIMT were measured 4.6 years (mean) later. Results: Mean age was 70 ± 11 years, and 64% were women. Fetuin-A levels were inversely associated with CAC severity. When evaluated as CAC categories (0, 1 to 100, 101 to 300, >300) with ordinal logistic regression, each SD higher fetuin-A was associated with 31% lower odds of CAC severity (proportional odds ratio: 0.69; 95% confidence interval: 0.46 to 0.92; p = 0.008) in models adjusted for demographic data, lifestyle factors, traditional CVD risk factors, and kidney function. In contrast, no association of fetuin-A was observed with PAD or high common or internal cIMT in adjusted models. Conclusions: Lower fetuin-A levels are independently associated with greater CAC severity but not PAD or cIMT. If confirmed, fetuin-A might mark calcium deposition within the vasculature but not atherosclerosis per se. © 2011 American College of Cardiology Foundation.

Cite

CITATION STYLE

APA

Ix, J. H., Barrett-Connor, E., Wassel, C. L., Cummins, K., Bergstrom, J., Daniels, L. B., & Laughlin, G. A. (2011). The associations of fetuin-a with subclinical cardiovascular disease in community-dwelling persons: The Rancho Bernardo study. Journal of the American College of Cardiology, 58(23), 2372–2379. https://doi.org/10.1016/j.jacc.2011.08.035

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free