The asymmetric total synthesis of four structural analogues of (+)-clusianone from a common advanced intermediate is described. Asymmetric induction is achieved through the use of enantioselective ACC alkylation, providing the common advanced intermediate with an er of 99:1.
Garnsey, M. R., Uteuliyev, M. M., & Coltart, D. M. (2015). Asymmetric synthesis of structural analogues of (+)-clusianone via enantioselective ACC alkylation. Tetrahedron Letters, 56(23), 3183–3185. https://doi.org/10.1016/j.tetlet.2015.01.012