ATM, MacroH2A.1, and SASP: The Checks and Balances of Cellular Senescence

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Abstract

Oncogene activation is usually not enough to induce cancer, but causes cells to arrest proliferation, alter chromatin structure, and increase protein secretion. In this issue of Molecular Cell, Chen et al. (2015) implicate the histone variant macroH2A.1 in the regulation of senescence. Oncogene activation is usually not enough to induce cancer, but causes cells to arrest proliferation, alter chromatin structure, and increase protein secretion. In this issue of Molecular Cell, Chen et al. (2015) implicate the histone variant macroH2A.1 in the regulation of senescence.

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Kozlowski, M., & Ladurner, A. G. (2015, September 3). ATM, MacroH2A.1, and SASP: The Checks and Balances of Cellular Senescence. Molecular Cell. Cell Press. https://doi.org/10.1016/j.molcel.2015.08.010

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