A-to-I editing: New and old sites, functions and speculations

118Citations
Citations of this article
66Readers
Mendeley users who have this article in their library.

Abstract

Nuclear pre-mRNA editing by selective adenosine deamination (A-to-I editing) occurs in all organisms from C. elegans to humans. This rare posttranscriptional mechanism can alter codons and hence the structure and function of proteins. New findings report new sites, give evidence that the efficiency of editing can be regulated by neurotransmitter, and reveal that an amino acid substitution introduced by editing into a neurotransmitter-gated ion channel subunit serves as a determinant for controlling the maturation, intracellular trafficking, and assembly with other subunits of this transmembrane protein.

Cite

CITATION STYLE

APA

Seeburg, P. H. (2002, July 3). A-to-I editing: New and old sites, functions and speculations. Neuron. Cell Press. https://doi.org/10.1016/S0896-6273(02)00760-2

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free