Autophagy Regulation of Metabolism Is Required for CD8 + T Cell Anti-tumor Immunity

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Abstract

DeVorkin et al. show that loss of autophagy enhances CD8 + T-cell-mediated rejection of tumors. Mechanistically, suppression of autophagy shifts T cells to a glycolytic phenotype and causes a reduction in S-adenosylmethionine. As a consequence, autophagy-deficient T cells transcriptionally reprogram immune response genes to an effector memory state.

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DeVorkin, L., Pavey, N., Carleton, G., Comber, A., Ho, C., Lim, J., … Lum, J. J. (2019). Autophagy Regulation of Metabolism Is Required for CD8 + T Cell Anti-tumor Immunity. Cell Reports, 27(2), 502-513.e5. https://doi.org/10.1016/j.celrep.2019.03.037

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