Efficacy of Combination of Silver-Nano Particles with Curcumin in Treatment of Inflammatory Bowel Disease (Ulcerative colitis) Through Rectal Route

Abstract

Background: Inflammatory bowel diseases (IBDs) are groups of chronic inflammatory disorders that had continuous recurrent swelling and irritation of the inner lining of the intestines. Nano Particles increase solubility and bioavailability of drugs. Curcumin is known for its wound-healing, antimicrobial, antioxidant, and anti-inflammatory properties. Aim of the work: our study aimed to evaluate efficacy of combination of silver nanoparticles with curcumin in the management of inflammatory bowel disease" through rectal route". Patients and Methods: the study was done from October 2023 to June 2024, included 90 participates with ulcerative colitis. Treatment Group: forty-five patients received a combination of silver-nanoparticles and curcumin via enema, and injection into the rectal ulcer and mucosa, along with oral mesalazine. Control Group: forty-five patients received a placebo saline enema with oral mesalazine. Disease severity was evaluated by clinical activity and endoscopic indices, at the start, every 2 months, and at the end of the 6-month trial. Results: The curcumin-treated group showed improvements in bowel frequency, defecation urgency, blood in stool, and overall well-being.". Extracolonic features of inflammatory bowel disease has been controlled. There was improvement in both clinical response and clinical remission when they were compared to patients treated with ordinary drugs. Evaluation by colonoscope for vascular pattern and erosions/ulcers showed wonderful healing rate in curcumin group and showed stoppage of bleeding due to healing of mucosa. Conclusion: Using Curcumin combined with Silver-Nano particles through rectal route can be effective as a treatment option of (IBDs) and improve patients’ quality of life.