Association between blastocyst morphology and outcome of single-blastocyst transfer

66Citations
Citations of this article
71Readers
Mendeley users who have this article in their library.

Abstract

The aim of this study was to assess the ability of three individual blastocyst morphology parameters-expansion and hatching (EH) stage, inner cell mass (ICM) grade and trophectoderm grade-to predict outcome of a cycle with single-blastocyst transfer. The study was a secondary analysis of data prospectively collected in a large multicentre trial. A total of 618 intracytoplasmic sperm injection patients undergoing ovarian stimulation in a gonadotrophin-releasing hormone antagonist cycle with compulsory single-blastocyst transfer on day 5 were included. In the simple logistic regression analysis, all three blastocyst morphology parameters were statistically significantly (P < 0.005 for each) associated with positive human chorionic gonadotrophin, clinical and ongoing pregnancy rates and live birth rates, while only the ICM grade was significantly (P = 0.033) associated with early pregnancy loss rate. Blastocyst EH stage was the only significant predictor of live birth (P = 0.002) in the multiple logistic regression. In conclusion, although all three blastocyst morphology parameters were related to treatment outcome of fresh single-blastocyst cycles, selection of high-quality blastocysts for transfer should consider first the EH stage. Transfer of a blastocyst with ICM grade A may reduce the risk of early pregnancy loss. © 2013, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

Cite

CITATION STYLE

APA

Van Den Abbeel, E., Balaban, B., Ziebe, S., Lundin, K., Cuesta, M. J. G., Klein, B. M., … Arce, J. C. (2013). Association between blastocyst morphology and outcome of single-blastocyst transfer. Reproductive BioMedicine Online, 27(4), 353–361. https://doi.org/10.1016/j.rbmo.2013.07.006

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free