Obesity, blood pressure, and retinal vessels: A meta-analysis

Abstract

CONTEXT: Retinal vessel imaging is a noninvasive diagnostic tool used to evaluate cardiovascular risk. Childhood obesity and elevated blood pressure (BP) are associated with retinal microvascular alterations. OBJECTIVE: To systematically review and meta-analyze associations between obesity, BP, and physical activity with retinal vessel diameters in children. DATA SOURCES: We conducted a literature search through the databases of PubMed, Embase, Ovid, Web of Science, and the Cochrane Register of Controlled Trials. STUDY SELECTION: School- and population-based cross-sectional data. DATA EXTRACTION: General information, study design, participants, exposure, and outcomes. RESULTS: A total of 1751 studies were found, and 30 full-text articles were analyzed for eligibility. Twenty-two articles (18865 children and adolescents) were used for further assessment and reflection. Eleven articles were finally included in the meta-analysis. We found that a higher BMI is associated with narrower retinal arteriolar (pooled estimate effect size ?0.37 [95% confidence interval (CI): ?0.50 to ?0.24]) and wider venular diameters (0.35 [95% CI: 0.07 to 0.63]). Systolic and diastolic BP are associated with retinal arteriolar narrowing (systolic BP: ?0.63 [95% CI: ?0.92 to ?0.34]; diastolic BP: ?0.60 [95% CI ?0.95 to ?0.25]). Increased physical activity and fitness are associated with favorable retinal vessel diameters. LIMITATIONS: Long-term studies are needed to substantiate the prognostic relevance of retinal vessel diameters for cardiovascular risk in children. CONCLUSIONS: Our results indicate that childhood obesity, BP, and physical inactivity are associated with retinal microvascular abnormalities. Retinal vessel diameters seem to be sensitive microvascular biomarkers for cardiovascular risk stratification in children.