Synthesis of new tetracyclic paullone derivatives as potential CDK inhibitors

Abstract

Synthetic efforts towards new tetracyclic heterocycles bearing the pyrrolo[2',3':5,6]azepino[4,3- b ] indol-4(11 H )-one core are described. Synthesized tetracyclic compounds are the first analogs, structurally related to protein kinase inhibitors paullones which incorporate an azepinone, an indole and a pyrrole ring. The synthetic approach involves palladium mediated intramolecular Heck coupling as a key step.