The genome of a novel nontoxigenic Corynebacterium diphtheriae, strain 5015, isolated from a patient with adenoid cystic carcinoma was sequenced and compared with 117 publically available genomes. This strain is phylogenetically distinct and lacks virulence genes encoding the toxin, BigA and Sdr-like adhesins. Strain 5015 possesses spaD-type and spaH-type pilus gene clusters with a loss of some gene functions, and 31 unique genes that need molecular characterization to understand their potential role in virulence characteristics.
Ramdhan, N. D., Blom, J., Sutcliffe, I. C., Pereira-Ribeiro, P. M. A., Santos, C. S., Mattos-Guaraldi, A. L., … Sangal, V. (2019). Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient. New Microbes and New Infections, 30. https://doi.org/10.1016/j.nmni.2019.100544