Successive Occurrence of T-Cell and B-Cell Lymphomas after Renal Transplantation in a Patient with Multiple Cutaneous Squamous-Cell Carcinomas

Abstract

ORGAN-TRANSPLANT recipients are prone to the development of cutaneous and extracutaneous malignant tumors. 1 , 2 Lymphomas occur in 1 to 2 percent of graft recipients and are usually of the B-cell type. 3 Cutaneous T-cell lymphomas are extremely rare. We describe a renal-transplant recipient with multiple cutaneous warts and squamous-cell carcinomas in whom a cutaneous T-cell lymphoma (Sézary syndrome) later developed, followed by a nodal B-cell lymphoma with immunoblastic components. Despite chemotherapy, the cutaneous T-cell lymphoma progressed rapidly, and the patient died within a year of the diagnosis. This case illustrates the role of immunosuppression in the development of multiple and complex malignant… © 1992, Massachusetts Medical Society. All rights reserved.