Photodynamic Therapy with Methylene Blue as Photosensitizer

Abstract

Availability of Methylene Blue as a photosensitizer in photodynamic therapy was investigated, and it was found that the HeLa cells incorporated with Methylene Blue was strongly damaged by the irradiation with laser light. Methylene Blue was effective for the irradiation of longer wavelength, which has the large tissue penetration depth. The possible reaction mechanism of the cell damage via photo-produced singlet oxygen is discussed. © 1993, The Chemical Society of Japan. All rights reserved.