Modifications of histone cores and tail in V(D)J recombination

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The organization of chromatin and modifications to the tails of histone proteins are thought to be important in regulating the rearrangement of V, D and J gene segments, which encode immunoglobulins and T-cell receptors. A recent study shows that methylated lysine 79 in the core region of histone H3 also plays a role by providing a euchromatic 'mark' that may regulate access of the V(D)J recombinase.




Muegge, K. (2003). Modifications of histone cores and tail in V(D)J recombination. Genome Biology.

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