Economic consequences of postinfarction prophylaxis with β blockers: Cost effectiveness of metoprolol

Abstract

Treatment with certain β adrenoceptor blocking agents after myocardial infarction reduces mortality and the incidence of reinfarction. Data from a randomised placebo controlled study of the β1 selective blocker metoprolol given as secondary prophylaxis were therefore analysed for the possible cost effectiveness of extending this treatment to the general population of patients with myocardial infarction. Metoprolol 100 mg twice daily and matching placebo were given to 154 and 147 patients, respectively, for three years. During this period drug costs for the β blocker, digitalis, and diuretics were analysed as well as costs of readmission for cardiac problems and indirect costs arising from sick leave or early retirement. Active treatment with metoprolol significantly reduced costs of readmission as well as indirect costs. The net effect per patient over the three years was a reduction of roughly kr 19 000 (£1930). These results suggest that β blocker treatment given as secondary prophylaxis after myocardial infarction is highly cost effective. © 1987, British Medical Journal Publishing Group. All rights reserved.