Protein import into the nucleus

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Abstract

The transport of proteins from the cytoplasm into the nucleus is a multistep process. The nuclear localization sequence (NLS) of a transport substrate associates with the heterodimeric NLS-receptor which binds to a subset of proteins of the nuclear pore complex (NPC). Translocation through the NPC is energy-dependent and requires the small GTPase Ran. Proteins that interact with Ran in either the GDP-bound or the GTP-bound state coordinate transfer through the NPC. Lastly, the NLS-receptor/substrate complex and Ran reach the nuclear side of the NPC where the complex disassembles.

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APA

Schlenstedt, G. (1996). Protein import into the nucleus. In FEBS Letters (Vol. 389, pp. 75–79). Elsevier B.V. https://doi.org/10.1016/0014-5793(96)00583-2

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