Population pharmacokinetic approach to the use of low dose cyclosporine in patients with connective tissue diseases

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Abstract

This study describes the population pharmacokinetics and dose personalization of cyclosporine in 36 patients with connective tissue diseases. A one-compartment open model with absorption was adopted as a pharmacokinetic model, and a nonlinear mixed effects model was used to analyze the population pharmacokinetic models. In the final model, age (AGE) and total body weight (TBW) were influential covariates on clearance (CL/F), which was expressed as CL/F (L/h)=17.8×(AGE/60)-0.269×(TBW/46.9)0.408, in addition to the volume of distribution (Vd/F), (L)=98.0 and absorption rate constant (Ka) (h-1)=0.67 (fixed). The results of the present study provide novel insights into factors involved in determining the most suitable dose and dosing strategy for individual patients with connective tissue disease.

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Tsuji, Y., Iwanaga, N., Mizoguchi, A., Sonemoto, E., Hiraki, Y., Ota, Y., … To, H. (2015). Population pharmacokinetic approach to the use of low dose cyclosporine in patients with connective tissue diseases. Biological and Pharmaceutical Bulletin, 38(9), 1265–1271. https://doi.org/10.1248/bpb.b15-00030

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