Synthesis and Biological Activity of Unsymmetrical Monoterpenylhetaryl Disulfides

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Abstract

New unsymmetrical monoterpenylhetaryl disulfides based on heterocyclic disulfides and monoterpene thiols were synthesized for the first time in 48–88% yields. Hydrolysis of disulfides with fragments of methyl esters of 2-mercaptonicotinic acid was carried out in 73–95% yields. The obtained compounds were evaluated for antioxidant, antibacterial, antifungal activity, cytotoxicity and mutagenicity.

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Sudarikov, D. V., Gyrdymova, Y. V., Borisov, A. V., Lukiyanova, J. M., Rumyantcev, R. V., Shevchenko, O. G., … Rubtsova, S. A. (2022). Synthesis and Biological Activity of Unsymmetrical Monoterpenylhetaryl Disulfides. Molecules, 27(16). https://doi.org/10.3390/molecules27165101

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