Extremely low-frequency electromagnetic fields increase the expression of anagen-related molecules in human dermal papilla cells via GSK-3Β/ERK/Akt signaling pathway

8Citations
Citations of this article
12Readers
Mendeley users who have this article in their library.

Abstract

Despite advances in medical treatments, the proportion of the population suffering from alopecia is increasing, thereby creating a need for new treatments to control hair loss and prevent balding. Human hair follicle dermal papilla cells (hDPCs), a type of specialized fibroblast in the hair bulb, play an essential role in controlling hair growth and in conditions like androgenic alopecia. This study aimed to evaluate the intensity-dependent effect of extremely low-frequency electromagnetic fields (ELF-EMFs) on the expression of anagen-related molecules in hDPCs in vitro. We examined the effect of ELF-EMF on hDPCs to determine whether activation of the GSK-3β/ERK/Akt signaling pathway improved hDPC activation and proliferation; hDPCs were exposed to ELF-EMFs at a frequency of 70 Hz and at intensities ranging from 5 to 100 G, over four days. Various PEMF intensities significantly increased the expression of anagen-related molecules, including collagen IV, laminin, ALP, and versican. In particular, an intensity of 10 G is most potent for promoting the proliferation of hDPC and expression of anagen-related molecules. Moreover, 10 G ELF-EMF significantly increased β-catenin and Wnt3α expression and GSK-3β/ERK/Akt phosphorylation. Our results confirmed that ELF-EMFs enhance hDPC activation and proliferation via the GSK-3β/ERK/Akt signaling pathway, suggesting a potential treatment strategy for alopecia.

Cite

CITATION STYLE

APA

Ki, G. E., Kim, Y. M., Lim, H. M., Lee, E. C., Choi, Y. K., & Seo, Y. K. (2020). Extremely low-frequency electromagnetic fields increase the expression of anagen-related molecules in human dermal papilla cells via GSK-3Β/ERK/Akt signaling pathway. International Journal of Molecular Sciences, 21(3). https://doi.org/10.3390/ijms21030784

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free