Immunosenescence : Penuaan Pada Sel Makrofag

Abstract

Immune function will decrease with age. The weakening of immune system is known as immunosenescence.Macrophages that play a major role in carrying out innate and adaptive immune functions have potential to undergoaging (macrophaging). Some potential mechanisms that can affect the aging of macrophages include telomereshortening, oxidative damage and impaired DNA repair processes. The impact of macrophaging can be a decreasenumber of macrophages in bone marrow, changing cytokine secretion, decreasing class II MHC expression, changingmacrophages polarization, decreasing ability of phagocytosis, and decreasing ability of wound repair and tissueregeneration.