During the past 4 years 196 patients with the idiopathic long QT syndrome were enrolled in a prospective international study conducted to obtain a better understanding of the clinical course of this unusual repolarization disorder. The mean patient age was 24 years, 64% were female, and 88% had family members with QT prolongation. During an average follow-up of 26 months per patient, four patients died suddenly (1.3% per year) and 27 patients had one or more syncopal episodes (8.6% per year). Multivariate analysis identified congenital deafness, history of syncope, female gender, and a documented episode of torsades de pointes or ventricular fibrillation as independent risk factors for postenrollment syncope or sudden death. Two types of treatment (left stellate ganglionectomy and β-blocker therapy) were associated with a significant reduction in the occurrence of cardiac events during follow-up.
CITATION STYLE
Moss, A. J., Schwartz, P. J., Crampton, R. S., Locati, E., & Carleen, E. (1985). The long QT syndrome: A prospective international study. Circulation, 71(1), 17–21. https://doi.org/10.1161/01.CIR.71.1.17
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