CREAM FORMULATION AND ANTIBACTERIAL TEST FOR ACNE MEDICATION FROM MICHELIA CHAMPACA L. FLOWER EXTRACT

Abstract

Acne is a problem that often arises in skin health, especially at the age of 14-19 years, although it can occur outside this age. The purpose of this study was to formulate and test the antibacterial acne cream from flower extract of Michelia champaca L. Acne drug formulations were divided into two types of formulas, namely type w/o and formula o/w, each of which consisted of 3 formulas. Evaluation of formulas included pH, viscosity and physical stability of the cream. Staphylococcus aureus ATC25923 and Staphylococcus epidermidis ATC12228 were selected for antibacterial tests. Physical stability testing of creams included color stability, odor and homogeneity which indicated no change during 56 days storage. The pH value decreased during time storage, but the pH value was still acceptable to the skin except for type w/o with a concentration of 12 MIC. The dose viscosity increased with increasing storage time. Using a method for dilution, the effect of bacteria decreased during time storage. Conclusions obtained on pH, viscosity, and antibacterial inhibitory power were based on statistics. The results of the study concluded that preparations with formula F3, formula o/w with a concentration of 7.5%, gave the best results. It is recommended to do further research for this cream formula clinically to patients who have acne problems.