Cardiac biomarkers for risk stratification in non-massive pulmonary embolism: A multicenter prospective study

Abstract

Background: Troponins (cTnI and cTnT), N-terminal pro-Brain Natriuretic Peptide (NT-proBNP), myoglobin, heart-type fatty acid-binding protein (H-FABP) and fibrin D-Dimer are emergent candidates for risk stratification in pulmonary embolism (PE). Objective: To compare the respective prognostic values of biomarker with non-massive PE to predict an adverse outcome at 3 months. Patients/Methods: One hundred and forty-six consecutive patients with non-massive PE were included in this multicenter prospective study. The combined outcome consisted of intensive care monitoring on admission, death or hospitalization attributable to either a PE-related complication [defined by PE/deep vein thrombosis (DVT) relapse or major bleeding under anticoagulation] or to dyspnoea with or without chest pain during follow-up. Results: The outcome was met in 12% of patients. In univariate analysis, a NT-proBNP level above 300pg/ml was the strongest predictor of unfavorable outcome with an odds ratio (OR) of 15.8 [95% confidence interval (CI): 2.05-122). ORs for the other variables were: 8.0 for D-dimer > 2000 ng/ml (95% CI: 1.1-64), 4.7 for H-FABP > 6 ng/ml (95% CI:1.5-14.8), 3.5 for cTnI > 0.09 ng/ml (95% CI:1.2-9.7), 3.4 for myoglobin > 70 ng/ml (95% CI:0.9-12.2). Receiver operating curve (ROC) analysis indicated that NT-proBNP was the best predictor [area under the curve (AUC) 0.84; 95% CI: 0.76-0.92; P < 0.0001] with a negative predictive value of 100% (95% CI: 91-100) at 300pg/ml. At that cut-off, the true negative rate for NT-proBNP was 40%. In multivariate analysis, NT-proBNP was the only significant independent predictors. Conclusions: NT-proBNP appears to be a good risk stratification marker in identifying low-risk patients with non-massive PE who could be treated in an outpatient setting. © 2009 International Society on Thrombosis and Haemostasis.