Paulomycin-related antibiotics: Paldimycins and antibiotics 273a2: Isolation and characterization

Abstract

The isolation of paulomycins A and B from fermentations of Streptomyces paulus has been reported earlier [J. Antibiotics 35: 285–294, 1982]. Further work on the antibiotics produced by S. paulus revealed the production of two paulomycin-related compounds, anti-biotics 273a1 and 273a2 which were isolated by procedures involving extractions and chroma-tography over buffered silica gel. Antibiotic 273a1 which has been named paldimycin, was found to be a mixture of two materials, paldimycins A and B (antibiotics 273a1a and 273a1β). Similarly, antibiotic 273a2 was found to consist of antibiotic 273a2aand antibiotic 273a2β. Paldimycin and antibiotic 273a2, which are produced by addition of two or one molecules of N-acetyl-L-cysteine, re-spectively, to paulomycins A and B, are active vs. Gram-positive bacteria. © 1987, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.