Cell-Based Therapy Approaches in Treatment of Non-obstructive Azoospermia

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Abstract

The rate of infertility has globally increased in recent years for a variety of reasons. One of the main causes of infertility in men is azoospermia that is defined by the absence of sperm in the ejaculate and classified into two categories: obstructive azoospermia and non-obstructive azoospermia. In non-obstructive azoospermia, genital ducts are not obstructed, but the testicles do not produce sperm at all, due to various reasons. Non-obstructive azoospermia in most cases has no therapeutic options other than assisted reproductive techniques, which in most cases require sperm donors. Here we discuss cell-based therapy approaches to restore fertility in men with non-obstructive azoospermia including cell-based therapies of non-obstructive azoospermia using regenerative medicine and cell-based therapies of non-obstructive azoospermia by paracrine and anti-inflammatory pathway, technical and ethical challenges for using different cell sources and alternative options will be described, and then the more effectual approaches will be mentioned as future trends.

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Roshandel, E., Mehravar, M., Nikoonezhad, M., Alizadeh, A. M., Majidi, M., Salimi, M., & Hajifathali, A. (2023, May 1). Cell-Based Therapy Approaches in Treatment of Non-obstructive Azoospermia. Reproductive Sciences. Institute for Ionics. https://doi.org/10.1007/s43032-022-01115-6

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