Kidney function is rarely studied in the context of blood kidney and urine as a system. Kidney can be considered as a black box, while plasma and urine proteomes closely represent the protein compositions of the input and output of the kidney. This idea provides a new approach for studying organ functions with a proteomic methodology. Because of its distinctive input (plasma) and output (urine), it is reasonable to predict that the kidney will be the first organ whose functions are further elucidated by proteomic methods in the near future.
Jia, L. (2015). Comparing plasma and urinary proteomes to understand kidney function. Advances in Experimental Medicine and Biology, 845, 187–193. https://doi.org/10.1007/978-94-017-9523-4_18