The Addition of Doxazosin to the Therapeutic Regimen of Hypertensive Patients Inadequately Controlled with Other Antihypertensive Medications: A Randomized, Placebo-Controlled Study

  • Black H
  • Sollins J
  • Garofalo J
43Citations
Citations of this article
11Readers
Mendeley users who have this article in their library.

Abstract

This randomized, double-blind, placebo-controlled study evaluated the use of doxazosin as an add-on therapy for inadequately controlled hypertension. Patients with a sitting diastolic blood pressure (BP) of 95 to 115 mm Hg received either doxazosin (n = 38) or placebo (n = 32) in addition to one or two baseline antihypertensive medications. After an upward titration period, patients were maintained on a fixed dosage of doxazosin (1 to 16 mg/day) or matching placebo for 4 weeks. Doxazosin add-on therapy led to improvements, compared with placebo, in sitting systolic BP (adjusted mean change = -20.9 v -8.5 mm Hg, P = .001), sitting diastolic BP (-13.0 v -8.1 mm Hg, P = .026), and standing systolic BP (-22.0 v -11.5 mm Hg, P = .011). Baseline antihypertensive therapy was gradually tapered or discontinued in patients who achieved a target reduction in BP (sitting diastolic BP of < 90 mm Hg in addition to a minimum improvement of 10 mm Hg in sitting diastolic BP over baseline) with add-on therapy (55% [n = 21] with doxazosin, 31% [n = 10] with placebo). Twelve patients in the doxazosin group maintained the target reduction in BP after complete withdrawal of their baseline antihypertensive therapy, compared with none in the placebo group. A small but statistically significant positive effect on the lipid profile was seen in the doxazosin group during add-on therapy. Doxazosin treatment was well tolerated, with an adverse event profile similar to that of placebo. These findings demonstrate that doxazosin add-on therapy is an effective, well-tolerated treatment strategy for patients with inadequately controlled hypertension. (C) 2000 American Journal of Hypertension, Ltd.

Cite

CITATION STYLE

APA

Black, H. R., Sollins, J. S., & Garofalo, J. L. (2000). The Addition of Doxazosin to the Therapeutic Regimen of Hypertensive Patients Inadequately Controlled with Other Antihypertensive Medications: A Randomized, Placebo-Controlled Study. American Journal of Hypertension, 13(5), 468–474. https://doi.org/10.1016/s0895-7061(99)00225-3

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free