Autoantibodies in Neuropsychiatric Disorders

  • Hoffmann C
  • Zong S
  • Mané-Damas M
  • et al.
Citations of this article
Mendeley users who have this article in their library.


Little is known about the etiology of neuropsychiatric disorders. The<br />identification of autoantibodies targeting the N-methyl-d-aspartate<br />receptor (NMDA-R), which causes neurological and psychiatric symptoms,<br />has reinvigorated the hypothesis that other patient subgroups may also<br />suffer from an underlying autoimmune condition. In recent years, a wide<br />range of neuropsychiatric diseases and autoantibodies targeting<br />ion-channels or neuronal receptors including NMDA-R, voltage gated<br />potassium channel complex (VGKC complex),<br />-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA-R),<br />-aminobutyric acid receptor (GABA-R) and dopamine receptor (DR) were<br />studied and conflicting reports have been published regarding the<br />seroprevalence of these autoantibodies. A clear causative role of<br />autoantibodies on psychiatric symptoms has as yet only been shown for<br />the NMDA-R. Several other autoantibodies have been related to the<br />presence of certain symptoms and antibody effector mechanisms have been<br />proposed. However, extensive clinical studies with large multicenter<br />efforts to standardize diagnostic procedures for autoimmune etiology and<br />animal studies are needed to confirm the pathogenicity of these<br />autoantibodies. In this review, we discuss the current knowledge of<br />neuronal autoantibodies in the major neuropsychiatric disorders:<br />psychotic, major depression, autism spectrum, obsessive-compulsive and<br />attention-deficit/hyperactivity disorders.




Hoffmann, C., Zong, S., Mané-Damas, M., Molenaar, P., Losen, M., & Martinez-Martinez, P. (2016). Autoantibodies in Neuropsychiatric Disorders. Antibodies, 5(2), 9.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free