Study of hepatic histomorphology in HBeAg+ and HBeAg− patients with CHB: Experience from Bangladesh

  • Mamun A
  • Mamun-Al-Mahtab
  • Akbar S
  • et al.
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Abstract

Objective: To compare Knodell and HAT scores in patients with wild type and pre-core/core promoter mutant CHB to see if there is an difference in se$\$erit) of lier injur) bebeen these two types of HBV. Methods: We did percutaneous liver biopsies of 155 CHB patients. Of them 102 (65.8{%}) were infected wild type HBV and the rest 53 (34.2{%}) were infected with pre-core/ core promoter mutant CHB. Results: 11/53 (20.8{%}) patients with pre-core/core promoter mutant CHB had moderate to severe CH (HAT score 8-18). Tn contrast, moderate to severe CH was seen in 19/102 (18.6{%}) patients with wild type CHB. Fibrosis score was {>}2 in 15/53 (28.3{%}) pre-core/core promoter mutant CHB as opposed to 20/102 (19.6{%}) patients with wild type CHB. Conclusions: The study shows that pre-core/core promoter mutant HBV produces more severe histological liver disease compared to wild type HBV.

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APA

Mamun, A. A., Mamun-Al-Mahtab, Akbar, S. M. F., Mollick, K. U., Tarafdar, A. J., Khondokar, F. A., … Rahman, S. (2013). Study of hepatic histomorphology in HBeAg+ and HBeAg− patients with CHB: Experience from Bangladesh. Journal of Acute Disease, 2(3), 232–235. https://doi.org/10.1016/s2221-6189(13)60133-x

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