Comparison of SCOUT DS, the ADA Diabetes Risk Test and Random Capillary Glucose for Diabetes Screening in At-Risk Populations

  • Maynard J
  • Barrack A
  • Murphree P
  • et al.
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Abstract

Screening at risk subjects for prediabetes and diabetes is an important step in prevention efforts. We examined the accuracy of random capillary glucose (RCG, common for mass screening) and two noninvasive screening methods, SCOUT DS and the ADA diabetes risk test (DRT) for detecting increasing levels of abnormal A1C. We pooled data from studies performed in the US, UK and Greece that shared methods and aims. A diabetes score was calculated from skin fluorescence measured on the left forearm with SCOUT DS. A finger prick was done to measure RCG and A1C. Age, sex, history of gestational diabetes, family history of diabetes, history of high blood pressure, physical activity, height and weight were used for the DRT. Dysglycemia was defined as A1C (greater-than or equal to) 5.7% or 6.0% and diabetes as A1C (greater-than or equal to) 6.5%. 1161 subjects had complete data for analysis with means for age and BMI of 50 yrs and 29 kg/m2. 31% were male. Prevalence of A1C (greater-than or equal to) 5.7%, (greater-than or equal to) 6.0% and (greater-than or equal to) 6.5% were 37%, 17% and 5%, respectively. Sensitivity (SENS), specificity (SPEC) and area under the curve (AUC) for detection of increasing levels of A1C are shown in Table 1. (Table presented) SCOUT DS and the ADA DRT had significantly greater AUC and SENS relative to RCG for detecting A1C-defined dysglycemia and diabetes. SCOUT DS had comparable AUC and SENS relative to the ADA DRT with significantly higher SPEC. Both noninvasive tests significantly outperformed RCG for diabetes screening with the added advantages of not requiring blood or causing pain

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APA

Maynard, J. D., Barrack, A., Murphree, P., Lathouris, P., Tentolouris, N., Londou, S., … Pope, R. (2013). Comparison of SCOUT DS, the ADA Diabetes Risk Test and Random Capillary Glucose for Diabetes Screening in At-Risk Populations. Canadian Journal of Diabetes, 37, S78. https://doi.org/10.1016/j.jcjd.2013.08.239

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