Honey incorporated antibacterial acellular dermal matrix for full-thickness wound healing

Abstract

Honey is a potent natural antibacterial remedy used for the treatment of chronic wounds. In this study, Honey incorporated Acellular Dermal Matrix (H-AGDM) was fabricated for accelerating the wound healing process. The physiochemical and morphological characterization of the fabricated matrix was performed by FTIR, FESEM, in vitro degradation study, and antibacterial activity. Subsequently the biocompatibility was evaluated by in vitro 3T3 cell culture study and in vivo by full-thickness wound healing study in albino mice model. H-AGDM significantly showed significantly enhanced antibacterial activity, biocompatibility, anti-inflammatory response and wound healing rate.