Butyrate Protects Mice from Clostridium difficile-Induced Colitis through an HIF-1-Dependent Mechanism

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Abstract

Fachi et al. demonstrate that butyrate is able to protect the intestinal epithelium from the damage caused by Clostridium difficile toxins by stabilizing HIF-1 and increasing tight junctions, which reduces intestinal epithelial permeability, thus inhibiting intestinal inflammation and bacterial translocation.

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Fachi, J. L., Felipe, J. de S., Pral, L. P., da Silva, B. K., Corrêa, R. O., de Andrade, M. C. P., … Vinolo, M. A. R. (2019). Butyrate Protects Mice from Clostridium difficile-Induced Colitis through an HIF-1-Dependent Mechanism. Cell Reports, 27(3), 750-761.e7. https://doi.org/10.1016/j.celrep.2019.03.054

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