Fachi et al. demonstrate that butyrate is able to protect the intestinal epithelium from the damage caused by Clostridium difficile toxins by stabilizing HIF-1 and increasing tight junctions, which reduces intestinal epithelial permeability, thus inhibiting intestinal inflammation and bacterial translocation.
Fachi, J. L., Felipe, J. de S., Pral, L. P., da Silva, B. K., Corrêa, R. O., de Andrade, M. C. P., … Vinolo, M. A. R. (2019). Butyrate Protects Mice from Clostridium difficile-Induced Colitis through an HIF-1-Dependent Mechanism. Cell Reports, 27(3), 750-761.e7. https://doi.org/10.1016/j.celrep.2019.03.054