A mild procedure for α,α-dichlorination of cyclic aryl ketones using commercial bleach

Abstract

α,α-Dichloro-cyclic aryl ketones were obtained treating a methanolic solution of the corresponding ketone with commercial bleach at ambient conditions in yields varying from 61 to 92%. Electron-donating and -withdrawing groups in the starting ketone are tolerated but the reaction appears to be sensitive to steric effects. Moreover, five-, six-, and seven-membered aryl-cycloalkanones can be used as substrate. ©2007 Sociedade Brasileira de Química.