Abstract
The mammalian genome comprises domains with varying ratios of A/T to G/C base pairs. The significance of mosaic base composition was unknown, but we discovered that the stem cell protein SALL4 reads A/T content to inhibit the expression of many genes, thereby stabilizing the pluripotent state.
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Pantier, R., Chhatbar, K., Quante, T., Skourti-Stathaki, K., Cholewa-Waclaw, J., Alston, G., … Bird, A. (2021). SALL4 controls cell fate in response to DNA base composition. Molecular Cell, 81(4), 845-858.e8. https://doi.org/10.1016/j.molcel.2020.11.046
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