Synthesis and biological evaluation of some imidazoline derivatives

Abstract

The group of imidazoline derivatives is an important class of compounds that possess broad biological activity. Many derivatives that have been efficiently synthesized form 4,5-dihydro-1H-imidazole s starting material to Synthesis of some new Schiff bases, 2-azetidinone and 4-thiazolidinone derivatives .The structures were characterized by FTIR and 1H-NMR spectra. All The synthesized compounds were evaluated for their antimicrobial activities against two kind of bacteria (gram +ve ) [ S .aureus, S.epidermi dis ] and (gram -ve ) [E.co li, Klebsiel lla spp] as well as fungi[C.albica ns] using the micro dilution procedure and compared with amoxicillin activity.