Periodontal regeneration of an intrabony osseous defect with combination of platelet rich fibrin and bovine derived demineralized bone matrix: A case report

Abstract

Background: The ultimate goal of periodontal therapy is regeneration of tissues destroyed by periodontal disease. Previously, various bone graft materials have been tried for management of osseous defects resulting from the disease process. However, the trend has now shifted towards application of endogenous regenerative therapy. The recent introduction of Choukroun's Platelet Rich Fibrin (PRF), has revolutionalized the field of dentistry. PRF, a rich source of autologous growth factors and cytokines, is an upcoming therapeutic approach in the management of periodontal osseous defects. Combination of autologous PRF and the otherwise commercially available bone grafts holds a promising potential of enhanced bone regeneration. Aim: The aim of this case report is to present the management of an intrabony osseous defect with combination of Platelet Rich Fibrin & Bovine derived demineralised bone matrix with clinical and radiographic evaluations for a 6 months follow up period. Material and Methods: A 40 year old female patient presented with the chief complaint of pain in relation to #13. Clinical evaluation revealed probing pocket depth (PPD) of 10mm and clinical attachment level (CAL) of 11mm distal to #13. Digital Radiographic analysis revealed angular bone loss in the region. Surgical therapy involved management by means of open flap debridement and placement of combination of autologous PRF and demineralized bone matrix in the combined wall defect. PRF was also used as membrane to secure the defect. Result: Post-operative evaluations revealed significant reduction in PPD and CAL gain at the end of 6 months. Also radiographic evidence of bone formation was observed as early as 3 months with almost complete fill by 6 months post-operatively. Conclusion: The combination therapy using platelet rich fibrin with demineralised bone matrix poses to be a rapid, effective and promising grafting modality for the management of intrabony osseous defects.