Pharmacokinetic interactions between intravenous ciprofloxacin and oral ferrous sulfate

Abstract

The changes in the bioavailability of oral antimicrobial activity in in vitro focus of many of the previous studies of the interaction of metal cations and quinolones. This study is the first to examine the possibility of interaction in the blood circulation using ciprofloxacin and ferrous sulfate as representative in the dogs model, and identify changes, if any, in the pharmaceutical antibiotics. To limit the direct physical interaction in the gastrointestinal. the current study design required the dogs (2.5 -3.5 Kg) to be dosed with 100 mg/kg of oral ferrous sulfate and 10 mg/kg of intravenous ciprofloxacin. Control animals received only intravenous ciprofloxacin. Blood samples were collected over time for quantitation of ciprofloxacin independently by HPLC assays. Results showed that the disposition of ciprofloxacin in control animals was biexponential with a (mean±SE) terminal elimination half-life (5.33 ± 0.14),(7.70 ± 0.08) respectively. The volume of distribution (Vd, 1.10± 0.15 L/kg), (Vd, 1.68 ± 0.33L/kg) was observed. When the antibiotic was dosed with oral iron, appeared to show a wider distribution and a longer elimination of ciprofloxacin relative to controls, antibiotic exposure (AUC 0-∞ ) was also significantly higher in the presence of iron (65.43 ± 1.60, 67.95 ± 1.78mg/ml/hr.). In conclusion, concomitant dosing oral iron lead to significant changes in the pharmacokinetics of intravenous and oral ciprofloxacin.