Solid-phase organic chemistry: Synthesis of 2β- (heterocyclylthiomethyl)penam derivatives on solid support

Abstract

The synthesis of 2β-(heterocyclylthiomethyl)penam derivatives on solid support has been developed. Compounds are obtained in good to high yields (based on loading of the original resin). The key step is the solid-phase double rearrangement of the corresponding penicillin sulfoxide.