Caffeine crosses the placenta and causes a number of complications. This study aims to review the effect of caffeine during pregnancy. Because of ion trapping weak bases that are non-ionized and lipophilic like caffeine diffuse across the placental barrier and become ionized in the more acidic fetal blood. A number of studies have reported the effect of caffeine on pregnancy. Some of the effects are diminishing fetal skeleton growth; risk of low birth weight (LBW); retardation of fetal development and/or intrauterine growth retardation (IUGR); adverse offspring childhood body fat distribution; increased risk of obesity; risk of type two diabetes mellitus; and Increased risk abortion. Even though a number of effects of caffeine are reported to be associated with pregnancy there are only a limited data showing causal association. Hence, avoiding the consumption of coffee, chocolate and tea during pregnancy appears prudent until more reliable evidences are emerging.
Woldu, M. A. (2017). The Effect of Caffeine on Pregnancy-Fact or Myth? Journal of Pregnancy and Child Health, 04(03). https://doi.org/10.4172/2376-127x.1000333