Extracellular matrix and cellular senescence in venous leg ulcers

11Citations
Citations of this article
57Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

High prevalence of non-healing chronic wounds contributes to a huge healthcare burden across the world. Early treatment interventions for non-healing wounds are vital. It was previously shown that accumulation of 15% or more of senescent cells in a chronic wound edge is an indicator that the wound is unlikely to heal. However, determining the presence of senescent cells would require invasive procedures such as tissue biopsies to be taken. In this study, we found a strong correlation between decreased collagen area and presence of senescent cells in human chronic wounds i.e. venous leg ulcer (VLU), diabetic foot ulcer (DFU) and pressure ulcer (PRU). We also report that the lowest collagen levels were found in VLU patients less than 60 years of age, with a persistent wound of > 24 months. Elevated levels of senescent cells were also found in VLU of males. Second harmonic imaging of collagen at the edge of chronic wounds with a handheld multiphoton device could be used to predict the number of senescent cells, indicating if the wound is on a healing trajectory or not. Our data support the use of collagen imaging in cutaneous wound assessment for a faster and non-invasive method to predict cellular senescence and determining wound trajectory of healing.

Cite

CITATION STYLE

APA

Lim, D. X. E., Richards, T., Kanapathy, M., Sudhaharan, T., Wright, G. D., Phillips, A. R. J., & Becker, D. L. (2021). Extracellular matrix and cellular senescence in venous leg ulcers. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-99643-9

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free