The Risk of Radiogenic Second Cancer Based on Differential DVH: Central Nervous System Malignant Tumor in Children

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Abstract

Objectives: To quantify the risk of radiogenic second cancer in pediatric patients receiving hippocampal-sparing craniospinal irradiation either with intensity-modulated radiation therapy or tomotherapy due to the development of a solid second cancer after radiotherapy using the concept of excess absolute risk. Methods: Computed tomography images of 15 pediatric patients who received craniospinal irradiation treatment were selected for this study. For each case, intensity-modulated radiation therapy and tomotherapy plans were computed. Then, the dosimetry parameters were analyzed. Differential dose–volume histograms were generated, and the excess absolute risks were calculated for each plan of each patient. Results: The tomotherapy group was superior to the intensity-modulated radiation therapy group in target area homogeneity index (P

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Tang, Z., Zou, X., Luo, Q., Wang, Y., & Jin, F. (2019). The Risk of Radiogenic Second Cancer Based on Differential DVH: Central Nervous System Malignant Tumor in Children. Technology in Cancer Research and Treatment, 18. https://doi.org/10.1177/1533033819886899

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