Mucins in cancer: Protection and control of the cell surface

Abstract

Mucins - large extracellular proteins that are heavily glycosylated with complex oligosaccharides - establish a selective molecular barrier at the epithelial surface and engage in morphogenetic signal transduction. Alterations in mucin expression or glycosylation accompany the development of cancer and influence cellular growth, differentiation, transformation, adhesion, invasion and immune surveillance. Mucins are used as diagnostic markers in cancer, and are under investigation as therapeutic targets for cancer.