NRP1 function and targeting in neurovascular development and eye disease

54Citations
Citations of this article
116Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Neuropilin 1 (NRP1) is expressed by neurons, blood vessels, immune cells and many other cell types in the mammalian body and binds a range of structurally and functionally diverse extracellular ligands to modulate organ development and function. In recent years, several types of mouse knockout models have been developed that have provided useful tools for experimental investigation of NRP1 function, and a multitude of therapeutics targeting NRP1 have been designed, mostly with the view to explore them for cancer treatment. This review provides a general overview of current knowledge of the signalling pathways that are modulated by NRP1, with particular focus on neuronal and vascular roles in the brain and retina. This review will also discuss the potential of NRP1 inhibitors for the treatment for neovascular eye diseases.

Cite

CITATION STYLE

APA

Raimondi, C., Brash, J. T., Fantin, A., & Ruhrberg, C. (2016, May 1). NRP1 function and targeting in neurovascular development and eye disease. Progress in Retinal and Eye Research. Elsevier Ltd. https://doi.org/10.1016/j.preteyeres.2016.02.003

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free