Abstract
Our recent study shows that the translation of MYC mRNA (mRNA) is controlled by its 3′ untranslated region (UTR) in a process that depends on the availability of glutamine and levels of cellular nucleotides. Metabolic feedback protects cells from a lethal glutamine addiction and may compromise metabolic targeting of glutamine metabolism.
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Royla, N., & Kempa, S. (2017). The answer’s in the tail: MYC mRNA has a metabolic sensor that supports cancer chemoresistance. Molecular and Cellular Oncology, 4(4). https://doi.org/10.1080/23723556.2017.1338209
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