Three-component process for the synthesis of 4-amino-5- Pyrimidinecarbonitriles under thermal aqueous conditions or microwave irradiation

Abstract

The three-component reaction of malononitrile, aldehydes and N-unsubstituted amidines, is extended to the formation of 4-amino-5- pyrimidinecarbonitrile derivatives. The reaction occurs in water at reflux or under microwave heating, in the presence of sodium acetate. This method provides a new route to produce pyrimidine derivatives in good to excellent yields. ©ARKAT USA, Inc.