Antidiabetic Activity of Some Extracts from Anisophyllea disticha Leaves

Abstract

Anisophyllea disticha has been being used as a traditional medicine by Talang Mamak tribe in Indragiri Hulu district, Riau province, Indonesia. The aim of this study was to evaluate antidiabetic properties of A.disticha leaves. The methanol extract was obtained by maceration, followed by successive partition process and yielded n-hexane, dichloromethane, and ethyl acetate fractions. Antidiabetic activity was determined by inhibiting the α-glucosidase activity method. The methanol extract showed high antidibetic activity followed by ethyl acetate fraction with IC50 value of 47.765 ± 0.127 and 50.883 ± 0.803 μg/mL, respectively. It could be concluded that leaves of A.disticha had antidiabetic properties.