Transgenic expression of microRNA-185 causes a developmental arrest of T cells by targeting multiple genes including Mzb1

Abstract

Background: MicroRNAs have critical roles in T cell development under normal and stress conditions. Results: Increasing miR-185 levels attenuate T cell development via the targeting of Mzb1, Nfatc3, and Camk4. Conclusion: Elevations in miR-185 impair thymopoiesis at several developmental stages. Significance: miR-185 levels are reduced in 22q11.2 deletion syndrome patients and the identification of its gene targets is clinically informative. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.