0669 ADVANCED SIGNAL PROCESSING OF NOCTURNAL POLYSOMNOGRAM IN PATIENTS WITH NARCOLEPSY AND IDIOPATHIC HYPERSOMNIA COMPARED TO CONTROLS AND CASES WITH A NOCTURNAL SOREMP

Abstract

Introduction: Narcolepsy with cataplexy (N-C) is characterized by destabilized sleep/wake and REM, but less is known about sleep structure in narcolepsy without cataplexy (NwC) and other hypersomnias. The goal of this study was to evaluate the microarchitecture of the NPSG in N-C and NwC cases compared to age/sex matched hypersomnia, SOREMP, and control cases. Methods: Fifty cases from each diagnostic group were sequestered from SleepMed's deidentified data repository (N=250). Patients on CNS medications were excluded. Controls were clinical cases with “normal” PSGs and low sleepiness (ESS<10). SOREMP cases were those with a PSG REM latency <15 min with otherwise normal PSGs and no indication of behavioral sleep or circadian abnormalities. Age and sex were similar for groups (Age=35+/-15 yr; 54% female, respectively), but race varied (% African American; narcolepsy=36%, hypersomnia= 10%, SOREMP=53%, controls=26%; p